iPPI-DB

Inhibitors of Protein-Protein Interaction Database

Compound 2452

Identifiers

  • Canonical SMILES: 
    Cc1cc(Cl)cc(c1CN1CCNCC1)-c1ccnc2cc(CN3C(=O)CCC3=O)sc12
  • IUPAC name: 
    1-[(7-{5-chloro-3-methyl-2-[(piperazin-1-yl)methyl]phenyl}thieno[3,2-b]pyridin-2-yl)methyl]pyrrolidine-2,5-dione
  • InChi: 
    InChI=1S/C24H25ClN4O2S/c1-15-10-16(25)11-19(20(15)14-28-8-6-26-7-9-28)18-4-5-27-21-12-17(32-24(18)21)13-29-22(30)2-3-23(29)31/h4-5,10-12,26H,2-3,6-9,13-14H2,1H3
  • InChiKey: 
    MJVNKLYUWIPXLC-UHFFFAOYSA-N

External links


146445185
CHEMBL4638960

External search

Bibliography (1)

Publication Name
Leger Paul R., Hu Dennis X., Biannic Berenger, Bui Minna, Han Xinping, Karbarz Emily, Maung Jack, Okano Akinori, Osipov Maksim, Shibuya Grant M., Young Kyle, Higgs Christopher, Abraham Betty, Bradford Delia, Cho Cynthia, Colas Christophe, Jacobson Scott, Ohol Yamini M., Pookot Deepa, Rana Payal, Sanchez Jerick, Shah Niket, Sun Michael, Wong Steve, Brockstedt Dirk G., Kassner Paul D., Schwarz Jacob B., Wustrow David J.. . Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity Journal of Medicinal Chemistry. 35

Pharmacological data

Biochemical tests Cellular tests PK tests Cytotoxicity tests
1 1 0 0

Targets

PPI family Best activity Diseases MMoA
USP7 / Ubiquitin 7.49 cancer Inhibition
Physicochemical filters
Descriptor Lipinski's RO5 Veber Pfizer's 3/75
Compliance
MW 468.14 g/mol
HBA 6
HBD 1
HBA + HBD 7
AlogP 3.30
TPSA 70.12
RB 5
Radar chart
PCA : iPPI-DB chemical space
PCA : Correlation circle
Efficiencies: iPPI-DB biplot LE versus LLE
Summary
Bibliographic ressources Biochemical tests Cellular tests PK tests Cytotoxicity tests
1 1 1 0 0
Pharmacological data
Bibliography Name Target Competition Assay type Assay name Cell line Activity type Activity
10.1021/acs.jmedchem.0c00245 35 UBP7
Q93009 		UBB
P0CG47 		Biochemical assay Fluorescence Polarization pIC50 (half maximal inhibitory concentration, -log10) 7.49
10.1021/acs.jmedchem.0c00245 35 UBP7
Q93009 		UBB
P0CG47 		Cellular assay p53-luciferase RKO pEC50 (half maximal effective concentration, -log10) 5.92
Ta Structure Name Drugbank ID
0.5302 2-({4-[(5-CHLORO-1H-INDOL-2-YL)SULFONYL]PIPERAZIN-1-YL}CARBONYL)THIENO[3,2-B]PYRIDINE 4-OXIDE DB07605
0.4952 PF-00356231 DB03367
0.4691 Encenicline DB11726
0.4550 5-CHLORO-N-((1R,2S)-2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO) CYCLOPENTYL)THIOPHENE-2-CARBOXAMIDE DB08174
0.4507 Pumosetrag DB12402
0.4357 THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [1-(1-AMINO-ISOQUINOLIN-7-YLMETHYL)-2-OXO-PYRROLDIN-3-YL]-AMIDE DB07261
0.4286 GLPG-0974 DB15406
0.4234 Ibodutant DB12042
0.4135 5-CHLORO-N-(2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO)ETHYL)THIOPHENE-2-CARBOXAMIDE DB08173
0.4134 RPR131247 DB02744
0.4122 5-Chloro-thiophene-2-carboxylic acid ((3S,4S)-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-4-hydroxy-pyrrolidin-3-yl)-amide DB07875
0.4096 (10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one DB07430
0.4093 5-chloro-N-[(3R)-1-(2-{[2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl]amino}-2-oxoethyl)pyrrolidin-3-yl]thiophene-2-carboxamide DB07872
0.4071 Sitravatinib DB15036
0.4070 THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [2-OXO-1-(1H-PYRROLO[2,3-C]PYRIDIN-2-YLMETHYL)-PYRROLIDIN-3-YL]-AMIDE DB08426