Compound 2024
Identifiers
- Common name: Fusicoccin A
- Canonical SMILES:
COC[C@H]1CC[C@@H]2C1C[C@@]1(C)[C@@H](O)CC([C@H](C)COC(C)=O)=C1[C@@H](O[C@H]1O[C@H](OCC(C)(C)C=C)C(O)C(OC(C)=O)C1O)[C@H](O)[C@@H]2C
- IUPAC name:
(2S)-2-[(3R,4S,8R,9R,10R,11R,14S)-8-{[(2S,6S)-4-(acetyloxy)-6-[(2,2-dimethylbut-3-en-1-yl)oxy]-3,5-dihydroxyoxan-2-yl]oxy}-4,9-dihydroxy-14-(methoxymethyl)-3,10-dimethyltricyclo[9.3.0.0^{3,7}]tetradec-6-en-6-yl]propyl acetate
- InChi:
InChI=1S/C36H58O12/c1-10-35(6,7)17-45-33-29(41)32(46-21(5)38)30(42)34(48-33)47-31-27-24(18(2)15-44-20(4)37)13-26(39)36(27,8)14-25-22(16-43-9)11-12-23(25)19(3)28(31)40/h10,18-19,22-23,25-26,28-34,39-42H,1,11-17H2,2-9H3/t18-,19-,22-,23+,25?,26+,28-,29?,30?,31-,32?,33+,34+,36+/m1/s1
- InChiKey:
PNWRSESCMBPWCI-CXISALMZSA-N
External links
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Bibliography (1)
Pharmacological data
Biochemical tests | Cellular tests | PK tests | Cytotoxicity tests |
---|---|---|---|
2 | 0 | 0 | 0 |
Targets
PPI family | Best activity | Diseases | MMoA |
---|---|---|---|
14-3-3 / TASK-like | 5.72 | cancer | Stabilization |
Physicochemical filters
Descriptor | Lipinski's RO5 | Veber | Pfizer's 3/75 | |
---|---|---|---|---|
Compliance | ||||
MW | 682.39 g/mol | |||
HBA | 12 | |||
HBD | 4 | |||
HBA + HBD | 16 | |||
AlogP | 2.36 | |||
TPSA | 170.44 | |||
RB | 14 |
Radar chart
PCA : iPPI-DB chemical space
PCA : Correlation circle
Efficiencies: iPPI-DB biplot LE versus LLE
Summary
Bibliographic ressources | Biochemical tests | Cellular tests | PK tests | Cytotoxicity tests |
---|---|---|---|---|
1 | 2 | 0 | 0 | 0 |
Pharmacological data
Bibliography | Name | Target | Competition | Assay type | Assay name | Cell line | Activity type | Activity |
---|---|---|---|---|---|---|---|---|
10.1016/j.chembiol.2013.03.015 | FC-A | |
|
Biochemical assay | Fluorescence Polarization | pEC50 (half maximal effective concentration, -log10) | 5.72 | |
10.1016/j.chembiol.2013.03.015 | FC-A | |
|
Biochemical assay | Fluorescence Polarization | Kd ratio (Kd without/with ligand | 29.20 |
Ta | Structure | Name | Drugbank ID |
---|---|---|---|
0.8491 | Fusicoccin | DB01780 | |
0.7636 | Narasin | DB11432 | |
0.7636 | Salinomycin | DB11544 | |
0.7454 | P-57AS3 | DB06569 | |
0.7431 | 9,10-Deepithio-9,10-Didehydroacanthifolicin | DB02169 | |
0.7264 | Oleandrin | DB12843 | |
0.7156 | Gitoformate | DB13537 | |
0.6759 | Lanatoside C | DB13467 | |
0.6729 | Acetyldigoxin | DB13691 | |
0.6729 | Acetyldigitoxin | DB00511 | |
0.6571 | Ouabain | DB01092 | |
0.6565 | Doramectin | DB11400 | |
0.6542 | Deslanoside | DB01078 | |
0.6449 | Metildigoxin | DB13401 | |
0.6449 | Rebaudioside A | DB15136 |