Compound 1984
Identifiers
- Canonical SMILES:
CN1C(=O)C(=Nc2ccccc2)c2ccccc12
- IUPAC name:
1-methyl-3-(phenylimino)-2,3-dihydro-1H-indol-2-one
- InChi:
InChI=1S/C15H12N2O/c1-17-13-10-6-5-9-12(13)14(15(17)18)16-11-7-3-2-4-8-11/h2-10H,1H3
- InChiKey:
LUEXNLDVPSVDKD-UHFFFAOYSA-N
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Bibliography (1)
Pharmacological data
Biochemical tests | Cellular tests | PK tests | Cytotoxicity tests |
---|---|---|---|
1 | 0 | 0 | 0 |
Targets
PPI family | Best activity | Diseases | MMoA |
---|---|---|---|
TTR | 4.96 | amyloidosis (disease) | Stabilization |
Physicochemical filters
Descriptor | Lipinski's RO5 | Veber | Pfizer's 3/75 | |
---|---|---|---|---|
Compliance | ||||
MW | 236.09 g/mol | |||
HBA | 3 | |||
HBD | 0 | |||
HBA + HBD | 3 | |||
AlogP | 2.98 | |||
TPSA | 32.67 | |||
RB | 1 |
Radar chart
PCA : iPPI-DB chemical space
PCA : Correlation circle
Efficiencies: iPPI-DB biplot LE versus LLE
Summary
Bibliographic ressources | Biochemical tests | Cellular tests | PK tests | Cytotoxicity tests |
---|---|---|---|---|
1 | 1 | 0 | 0 | 0 |
Pharmacological data
Bibliography | Name | Target | Competition | Assay type | Assay name | Cell line | Activity type | Activity |
---|---|---|---|---|---|---|---|---|
10.1016/j.bmcl.2009.03.004 | 2b | TTHY P02766 |
|
Biochemical assay | Kinetic turbidimetric | pIC50 (half maximal inhibitory concentration, -log10) | 4.96 |
Ta | Structure | Name | Drugbank ID |
---|---|---|---|
0.9074 | (3e)-3-[(4-Hydroxyphenyl)Imino]-1h-Indol-2(3h)-One | DB03650 | |
0.5489 | Metisazone | DB13641 | |
0.5089 | Isatin | DB02095 | |
0.5000 | Oxyphenisatin | DB04823 | |
0.4874 | Ropinirole | DB00268 | |
0.4841 | Amedalin | DB09188 | |
0.4580 | 3-[4-(1-formylpiperazin-4-yl)-benzylidenyl]-2-indolinone | DB02058 | |
0.4574 | Pyroquilon | DB02756 | |
0.4574 | Oxyphenisatin acetate | DB14627 | |
0.4493 | Linopirdine | DB13806 | |
0.4390 | AR-42 | DB12707 | |
0.4336 | Nordazepam | DB14028 | |
0.4336 | Diazepam | DB00829 | |
0.4333 | Pactimibe | DB12971 | |
0.4324 | Delorazepam | DB01511 |