Compound 1909
Identifiers
- Common name: benzo-triazepine
- Canonical SMILES:
CN1N=C(c2ccccc2)c2cc(Cl)ccc2-n2c(C)nnc12
- IUPAC name:
12-chloro-3,7-dimethyl-9-phenyl-2,4,5,7,8-pentaazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,8,11,13-hexaene
- InChi:
InChI=1S/C17H14ClN5/c1-11-19-20-17-22(2)21-16(12-6-4-3-5-7-12)14-10-13(18)8-9-15(14)23(11)17/h3-10H,1-2H3
- InChiKey:
UYIVCPRWMLOCSB-UHFFFAOYSA-N
External links
![]() 20350618 |
![]() CHEMBL1958337 |
08K |
External search
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Bibliography (1)
Pharmacological data
Biochemical tests | Cellular tests | PK tests | Cytotoxicity tests |
---|---|---|---|
1 | 0 | 0 | 0 |
Targets
PPI family | Best activity | Diseases | MMoA |
---|---|---|---|
Bromodomain / Histone | 6.19 | cancer | Inhibition |
Physicochemical filters
Descriptor | Lipinski's RO5 | Veber | Pfizer's 3/75 | |
---|---|---|---|---|
Compliance | ||||
MW | 323.09 g/mol | |||
HBA | 5 | |||
HBD | 0 | |||
HBA + HBD | 5 | |||
AlogP | 3.84 | |||
TPSA | 46.31 | |||
RB | 1 |
Radar chart
PCA : iPPI-DB chemical space
PCA : Correlation circle
Efficiencies: iPPI-DB biplot LE versus LLE
Summary
Bibliographic ressources | Biochemical tests | Cellular tests | PK tests | Cytotoxicity tests |
---|---|---|---|---|
1 | 1 | 0 | 0 | 0 |
Pharmacological data
Bibliography | Name | Target | Competition | Assay type | Assay name | Cell line | Activity type | Activity |
---|---|---|---|---|---|---|---|---|
10.1016/j.bmc.2011.10.080 | BzT-7 | H4 P62805 |
BRD4 O60885 |
Biochemical assay | Isothermal Titration Calorimetry | pKd (dissociation constant, -log10) | 6.19 |
Ta | Structure | Name | Drugbank ID |
---|---|---|---|
0.5246 | Estazolam | DB01215 | |
0.5187 | Alprazolam | DB00404 | |
0.5052 | Triazolam | DB00897 | |
0.4975 | Adinazolam | DB00546 | |
0.4381 | Clonazolam | DB14716 | |
0.4048 | Nitrazolam | DB14717 | |
0.3925 | Pyrazolam | DB14718 | |
0.3891 | Midazolam | DB00683 | |
0.3582 | Gandotinib | DB13040 | |
0.3438 | Apilimod | DB05611 | |
0.3436 | Etizolam | DB09166 | |
0.3427 | AC-430 | DB12535 | |
0.3372 | Brotizolam | DB09017 | |
0.3367 | 4-[4-AMINO-6-(5-CHLORO-1H-INDOL-4-YLMETHYL)-[1,3,5]TRIAZIN-2-YLAMINO]-BENZONITRILE | DB07337 | |
0.3363 | (2S)-2-{[3-(3-aminophenyl)imidazo[1,2-b]pyridazin-6-yl]amino}-3-methylbutan-1-ol | DB08004 |