Compound 1876
Identifiers
- Canonical SMILES:
Cn1cc(-c2ccccc2Oc2ccccc2)c2cc[nH]c(=O)c12
- IUPAC name:
1-methyl-3-(2-phenoxyphenyl)-1H,6H,7H-pyrrolo[2,3-c]pyridin-7-one
- InChi:
InChI=1S/C20H16N2O2/c1-22-13-17(16-11-12-21-20(23)19(16)22)15-9-5-6-10-18(15)24-14-7-3-2-4-8-14/h2-13H,1H3,(H,21,23)
- InChiKey:
LXTIJBUYZHCORC-UHFFFAOYSA-N
External links
![]() 86287687 |
![]() CHEMBL4103937 |
87G |
External search
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Bibliography (1)
Pharmacological data
Biochemical tests | Cellular tests | PK tests | Cytotoxicity tests |
---|---|---|---|
1 | 2 | 0 | 0 |
Targets
PPI family | Best activity | Diseases | MMoA |
---|---|---|---|
Bromodomain / Histone | 6.92 | cancer | Inhibition |
Physicochemical filters
Descriptor | Lipinski's RO5 | Veber | Pfizer's 3/75 | |
---|---|---|---|---|
Compliance | ||||
MW | 316.12 g/mol | |||
HBA | 4 | |||
HBD | 1 | |||
HBA + HBD | 5 | |||
AlogP | 3.70 | |||
TPSA | 43.26 | |||
RB | 3 |
Radar chart
PCA : iPPI-DB chemical space
PCA : Correlation circle
Efficiencies: iPPI-DB biplot LE versus LLE
Summary
Bibliographic ressources | Biochemical tests | Cellular tests | PK tests | Cytotoxicity tests |
---|---|---|---|---|
1 | 1 | 2 | 0 | 0 |
Pharmacological data
Bibliography | Name | Target | Competition | Assay type | Assay name | Cell line | Activity type | Activity |
---|---|---|---|---|---|---|---|---|
10.1016/j.bmcl.2017.02.057 | 34 | BRD4 O60885 |
H4 P62805 |
Biochemical assay | Time-Resolved FRET | pKi (inhibition constant, -log10) | 6.92 | |
10.1016/j.bmcl.2017.02.057 | 34 | BRD4 O60885 |
H4 P62805 |
Cellular assay | MX-1 proliferation assay | MX-1 | pEC50 (half maximal effective concentration, -log10) | 6.24 |
10.1016/j.bmcl.2017.02.057 | 34 | BRD4 O60885 |
H4 P62805 |
Cellular assay | Luciferase reporter | H1299 | pEC50 (half maximal effective concentration, -log10) | 5.96 |
Ta | Structure | Name | Drugbank ID |
---|---|---|---|
0.5096 | 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE | DB08350 | |
0.5033 | 4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol | DB06898 | |
0.4765 | 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine | DB08398 | |
0.4667 | Voxtalisib | DB12400 | |
0.4634 | 3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one | DB07528 | |
0.4634 | Dactolisib | DB11651 | |
0.4602 | Dasabuvir | DB09183 | |
0.4581 | 6-(2,6-DIMETHOXYPHENYL)PYRIDO[2,3-D]PYRIMIDINE-2,7-DIAMINE | DB08145 | |
0.4546 | Hydronidone | DB06299 | |
0.4413 | 2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide | DB08583 | |
0.4407 | 9-HYDROXY-6-(3-HYDROXYPROPYL)-4-(2-METHOXYPHENYL)PYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE | DB07006 | |
0.4384 | Merestinib | DB12381 | |
0.4358 | [5-(5-Amino-1H-pyrrolo[3,2-b]pyridin-2-yl)-6-hydroxy-3'-nitro-3-biphenylyl]acetic acid | DB08232 | |
0.4323 | Garenoxacin | DB06160 | |
0.4320 | 9-(4-Hydroxyphenyl)-2,7-Phenanthroline | DB03623 |