Compound 1874
Identifiers
- Canonical SMILES:
Cc1[nH]c(-c2ccccc2Oc2ccccc2)c2nc[nH]c(=O)c12
- IUPAC name:
5-methyl-7-(2-phenoxyphenyl)-3H,4H,6H-pyrrolo[3,4-d]pyrimidin-4-one
- InChi:
InChI=1S/C19H15N3O2/c1-12-16-18(20-11-21-19(16)23)17(22-12)14-9-5-6-10-15(14)24-13-7-3-2-4-8-13/h2-11,22H,1H3,(H,20,21,23)
- InChiKey:
GBBSZTYFIKCEPZ-UHFFFAOYSA-N
External links
![]() 86271653 |
![]() CHEMBL4076251 |
External search
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Bibliography (1)
Pharmacological data
Biochemical tests | Cellular tests | PK tests | Cytotoxicity tests |
---|---|---|---|
1 | 2 | 0 | 0 |
Targets
PPI family | Best activity | Diseases | MMoA |
---|---|---|---|
Bromodomain / Histone | 5.96 | cancer | Inhibition |
Physicochemical filters
Descriptor | Lipinski's RO5 | Veber | Pfizer's 3/75 | |
---|---|---|---|---|
Compliance | ||||
MW | 317.12 g/mol | |||
HBA | 5 | |||
HBD | 2 | |||
HBA + HBD | 7 | |||
AlogP | 3.07 | |||
TPSA | 66.48 | |||
RB | 3 |
Radar chart
PCA : iPPI-DB chemical space
PCA : Correlation circle
Efficiencies: iPPI-DB biplot LE versus LLE
Summary
Bibliographic ressources | Biochemical tests | Cellular tests | PK tests | Cytotoxicity tests |
---|---|---|---|---|
1 | 1 | 2 | 0 | 0 |
Pharmacological data
Bibliography | Name | Target | Competition | Assay type | Assay name | Cell line | Activity type | Activity |
---|---|---|---|---|---|---|---|---|
10.1016/j.bmcl.2017.02.057 | 32 | BRD4 O60885 |
H4 P62805 |
Biochemical assay | Time-Resolved FRET | pKi (inhibition constant, -log10) | 5.96 | |
10.1016/j.bmcl.2017.02.057 | 32 | BRD4 O60885 |
H4 P62805 |
Cellular assay | MX-1 proliferation assay | MX-1 | pEC50 (half maximal effective concentration, -log10) | 5.92 |
10.1016/j.bmcl.2017.02.057 | 32 | BRD4 O60885 |
H4 P62805 |
Cellular assay | Luciferase reporter | H1299 | pEC50 (half maximal effective concentration, -log10) | 5.80 |
Ta | Structure | Name | Drugbank ID |
---|---|---|---|
0.4908 | 6-(2,6-DIMETHOXYPHENYL)PYRIDO[2,3-D]PYRIMIDINE-2,7-DIAMINE | DB08145 | |
0.4785 | Lorecivivint | DB14883 | |
0.4649 | CRA_17312 | DB02084 | |
0.4598 | 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE | DB08350 | |
0.4593 | 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid | DB08299 | |
0.4522 | 2-{2-hydroxy-[1,1'-biphenyl]-3-yl}-1H-1,3-benzodiazole-5-carboximidamide | DB01725 | |
0.4444 | 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE | DB07364 | |
0.4405 | CRA_23653 | DB04246 | |
0.4346 | [5-(5-Amino-1H-pyrrolo[3,2-b]pyridin-2-yl)-6-hydroxy-3'-nitro-3-biphenylyl]acetic acid | DB08232 | |
0.4328 | Mirodenafil | DB11792 | |
0.4294 | 3-AMINO-3-BENZYL-[4.3.0]BICYCLO-1,6-DIAZANONAN-2-ONE | DB07655 | |
0.4286 | 6-AMINO-4-[2-(4-METHOXYPHENYL)ETHYL]-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE | DB07704 | |
0.4250 | 2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine | DB01905 | |
0.4246 | TG100-115 | DB05552 | |
0.4241 | Linsitinib | DB06075 |