iPPI-DB

Inhibitors of Protein-Protein Interaction Database

Compound 1853

Identifiers

  • Canonical SMILES: 
    Cc1[nH]c(cc1C(N)=O)-c1cc(N)ccc1Oc1ccccc1
  • IUPAC name: 
    5-(5-amino-2-phenoxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide
  • InChi: 
    InChI=1S/C18H17N3O2/c1-11-14(18(20)22)10-16(21-11)15-9-12(19)7-8-17(15)23-13-5-3-2-4-6-13/h2-10,21H,19H2,1H3,(H2,20,22)
  • InChiKey: 
    CUUGHSOYWQABPW-UHFFFAOYSA-N

External links


90413429
CHEMBL4088536

External search

Bibliography (1)

Publication Name
Hasvold Lisa A., Sheppard George S., Wang Le, Fidanze Steven D., Liu Dachun, Pratt John K., Mantei Robert A., Wada Carol K., Hubbard Robbert, Shen Yu, Lin Xiaoyu, Huang Xiaoli, Warder Scott E., Wilcox Denise, Li Leiming, Buchanan F. Greg, Smithee Lauren, Albert Daniel H., Magoc Terrance J., Park Chang H., Petros Andrew M., Panchal Sanjay C., Sun Chaohong, Kovar Peter, Soni Nirupama B., Elmore Steven W., Kati Warren M., McDaniel Keith F.. . Methylpyrrole inhibitors of BET bromodomains Bioorganic & Medicinal Chemistry Letters. 11

Pharmacological data

Biochemical tests Cellular tests PK tests Cytotoxicity tests
1 2 0 0

Targets

PPI family Best activity Diseases MMoA
Bromodomain / Histone 6.38 cancer Inhibition
Physicochemical filters
Descriptor Lipinski's RO5 Veber Pfizer's 3/75
Compliance
MW 307.13 g/mol
HBA 5
HBD 5
HBA + HBD 10
AlogP 2.34
TPSA 94.13
RB 4
Radar chart
PCA : iPPI-DB chemical space
PCA : Correlation circle
Efficiencies: iPPI-DB biplot LE versus LLE
Summary
Bibliographic ressources Biochemical tests Cellular tests PK tests Cytotoxicity tests
1 1 2 0 0
Pharmacological data
Bibliography Name Target Competition Assay type Assay name Cell line Activity type Activity
10.1016/j.bmcl.2017.02.057 11 BRD4
O60885 		H4
P62805 		Biochemical assay Time-Resolved FRET pKi (inhibition constant, -log10) 6.38
10.1016/j.bmcl.2017.02.057 11 BRD4
O60885 		H4
P62805 		Cellular assay MX-1 proliferation assay MX-1 pEC50 (half maximal effective concentration, -log10) 6.16
10.1016/j.bmcl.2017.02.057 11 BRD4
O60885 		H4
P62805 		Cellular assay Luciferase reporter H1299 pEC50 (half maximal effective concentration, -log10) 6.06
Ta Structure Name Drugbank ID
0.5055 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DB08358
0.5000 [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA DB07247
0.4932 2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide DB04010
0.4906 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE DB08350
0.4778 2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DB07728
0.4571 9-HYDROXY-6-(3-HYDROXYPROPYL)-4-(2-METHOXYPHENYL)PYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE DB07006
0.4552 2,3-diphenyl-1H-indole-7-carboxylic acid DB08709
0.4503 2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide DB03509
0.4464 Losmapimod DB12270
0.4460 3-{5-[AMINO(IMINIO)METHYL]-1H-INDOL-2-YL}-5-METHOXY-1,1'-BIPHENYL-2-OLATE DB07229
0.4452 2-{2-hydroxy-[1,1'-biphenyl]-3-yl}-1H-1,3-benzodiazole-5-carboximidamide DB01725
0.4451 Talnetant DB06429
0.4348 CRA_8696 DB03159
0.4286 Oxycinchophen DB13596
0.4270 CRA_17312 DB02084