Compound 1851
Identifiers
- Canonical SMILES:
Cc1[nH]c(cc1C(N)=O)-c1ccccc1Oc1ccc(Cl)cc1
- IUPAC name:
5-[2-(4-chlorophenoxy)phenyl]-2-methyl-1H-pyrrole-3-carboxamide
- InChi:
InChI=1S/C18H15ClN2O2/c1-11-15(18(20)22)10-16(21-11)14-4-2-3-5-17(14)23-13-8-6-12(19)7-9-13/h2-10,21H,1H3,(H2,20,22)
- InChiKey:
VYHWNVJEEBHTKR-UHFFFAOYSA-N
External links
![]() 90413480 |
![]() CHEMBL4098863 |
87S |
External search
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Bibliography (1)
Pharmacological data
Biochemical tests | Cellular tests | PK tests | Cytotoxicity tests |
---|---|---|---|
1 | 2 | 0 | 0 |
Targets
PPI family | Best activity | Diseases | MMoA |
---|---|---|---|
Bromodomain / Histone | 6.55 | cancer | Inhibition |
Physicochemical filters
Descriptor | Lipinski's RO5 | Veber | Pfizer's 3/75 | |
---|---|---|---|---|
Compliance | ||||
MW | 326.08 g/mol | |||
HBA | 4 | |||
HBD | 3 | |||
HBA + HBD | 7 | |||
AlogP | 3.77 | |||
TPSA | 68.11 | |||
RB | 4 |
Radar chart
PCA : iPPI-DB chemical space
PCA : Correlation circle
Efficiencies: iPPI-DB biplot LE versus LLE
Summary
Bibliographic ressources | Biochemical tests | Cellular tests | PK tests | Cytotoxicity tests |
---|---|---|---|---|
1 | 1 | 2 | 0 | 0 |
Pharmacological data
Bibliography | Name | Target | Competition | Assay type | Assay name | Cell line | Activity type | Activity |
---|---|---|---|---|---|---|---|---|
10.1016/j.bmcl.2017.02.057 | 9 | BRD4 O60885 |
H4 P62805 |
Biochemical assay | Time-Resolved FRET | pKi (inhibition constant, -log10) | 6.39 | |
10.1016/j.bmcl.2017.02.057 | 9 | BRD4 O60885 |
H4 P62805 |
Cellular assay | MX-1 proliferation assay | MX-1 | pEC50 (half maximal effective concentration, -log10) | 5.92 |
10.1016/j.bmcl.2017.02.057 | 9 | BRD4 O60885 |
H4 P62805 |
Cellular assay | Luciferase reporter | H1299 | pEC50 (half maximal effective concentration, -log10) | 6.55 |
Ta | Structure | Name | Drugbank ID |
---|---|---|---|
0.4730 | 2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide | DB04010 | |
0.4698 | 2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide | DB03509 | |
0.4696 | 2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE | DB07728 | |
0.4690 | [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA | DB07247 | |
0.4574 | 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE | DB08358 | |
0.4490 | 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine | DB03865 | |
0.4489 | 9-HYDROXY-6-(3-HYDROXYPROPYL)-4-(2-METHOXYPHENYL)PYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE | DB07006 | |
0.4487 | CRA_10762 | DB02366 | |
0.4451 | Talnetant | DB06429 | |
0.4451 | 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE | DB08350 | |
0.4294 | Losmapimod | DB12270 | |
0.4286 | Oxycinchophen | DB13596 | |
0.4177 | 9-HYDROXY-4-PHENYL-6H-PYRROLO[3,4-C]CARBAZOLE-1,3-DIONE | DB04608 | |
0.4172 | 3-{5-[AMINO(IMINIO)METHYL]-1H-INDOL-2-YL}-5-METHOXY-1,1'-BIPHENYL-2-OLATE | DB07229 | |
0.4161 | 2,3-diphenyl-1H-indole-7-carboxylic acid | DB08709 |