Compound 1847
Identifiers
- Canonical SMILES:
Cc1[nH]c(cc1C(N)=O)-c1ccccc1N
- IUPAC name:
5-(2-aminophenyl)-2-methyl-1H-pyrrole-3-carboxamide
- InChi:
InChI=1S/C12H13N3O/c1-7-9(12(14)16)6-11(15-7)8-4-2-3-5-10(8)13/h2-6,15H,13H2,1H3,(H2,14,16)
- InChiKey:
UBOQKPCXNYZXEW-UHFFFAOYSA-N
External links
![]() 86299506 |
![]() CHEMBL4073935 |
External search
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Bibliography (1)
Pharmacological data
Biochemical tests | Cellular tests | PK tests | Cytotoxicity tests |
---|---|---|---|
1 | 0 | 0 | 0 |
Targets
PPI family | Best activity | Diseases | MMoA |
---|---|---|---|
Bromodomain / Histone | 4.66 | cancer | Inhibition |
Physicochemical filters
Descriptor | Lipinski's RO5 | Veber | Pfizer's 3/75 | |
---|---|---|---|---|
Compliance | ||||
MW | 215.11 g/mol | |||
HBA | 4 | |||
HBD | 5 | |||
HBA + HBD | 9 | |||
AlogP | 0.84 | |||
TPSA | 84.90 | |||
RB | 2 |
Radar chart
PCA : iPPI-DB chemical space
PCA : Correlation circle
Efficiencies: iPPI-DB biplot LE versus LLE
Summary
Bibliographic ressources | Biochemical tests | Cellular tests | PK tests | Cytotoxicity tests |
---|---|---|---|---|
1 | 1 | 0 | 0 | 0 |
Pharmacological data
Bibliography | Name | Target | Competition | Assay type | Assay name | Cell line | Activity type | Activity |
---|---|---|---|---|---|---|---|---|
10.1016/j.bmcl.2017.02.057 | 4 | BRD4 O60885 |
H4 P62805 |
Biochemical assay | Time-Resolved FRET | pKi (inhibition constant, -log10) | 4.66 |
Ta | Structure | Name | Drugbank ID |
---|---|---|---|
0.5526 | 2,3-diphenyl-1H-indole-7-carboxylic acid | DB08709 | |
0.5467 | 2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE | DB07728 | |
0.5289 | 2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide | DB03509 | |
0.5287 | 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE | DB08358 | |
0.5145 | Losmapimod | DB12270 | |
0.5143 | Cinchophen | DB13551 | |
0.4878 | Brequinar Analog | DB03480 | |
0.4839 | Brequinar | DB03523 | |
0.4839 | 2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide | DB04010 | |
0.4722 | 2-(2-METHYLPHENYL)-1H-INDOLE-6-CARBOXIMIDAMIDE | DB06918 | |
0.4712 | 2-(3-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDE | DB06923 | |
0.4672 | [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA | DB07247 | |
0.4667 | Esaxerenone | DB15207 | |
0.4615 | 9-HYDROXY-4-PHENYL-6H-PYRROLO[3,4-C]CARBAZOLE-1,3-DIONE | DB04608 | |
0.4604 | Talnetant | DB06429 |