Compound 1452
Identifiers
- Canonical SMILES:
NC(=O)c1nc(-c2ccccc2F)n(c1-c1cccc(Cl)c1)-c1cccc(Cl)c1
- InChi:
InChI=1S/C22H14Cl2FN3O/c23-14-6-3-5-13(11-14)20-19(21(26)29)27-22(17-9-1-2-10-18(17)25)28(20)16-8-4-7-15(24)12-16/h1-12H,(H2,26,29)
- InChiKey:
HACSGRDYTYKDCL-UHFFFAOYSA-N
External links
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Bibliography (1)
Pharmacological data
Biochemical tests | Cellular tests | PK tests | Cytotoxicity tests |
---|---|---|---|
1 | 0 | 0 | 0 |
Targets
PPI family | Best activity | Diseases | MMoA |
---|---|---|---|
MDM2-Like / P53 | 4.83 | cancer | Inhibition |
Physicochemical filters
Descriptor | Lipinski's RO5 | Veber | Pfizer's 3/75 | |
---|---|---|---|---|
Compliance | ||||
MW | 425.05 g/mol | |||
HBA | 4 | |||
HBD | 2 | |||
HBA + HBD | 6 | |||
AlogP | 5.13 | |||
TPSA | 60.91 | |||
RB | 4 |
Radar chart
PCA : iPPI-DB chemical space
PCA : Correlation circle
Efficiencies: iPPI-DB biplot LE versus LLE
Summary
Bibliographic ressources | Biochemical tests | Cellular tests | PK tests | Cytotoxicity tests |
---|---|---|---|---|
1 | 1 | 0 | 0 | 0 |
Pharmacological data
Bibliography | Name | Target | Competition | Assay type | Assay name | Cell line | Activity type | Activity |
---|---|---|---|---|---|---|---|---|
WO2011023677 | 112 | MDM2 Q00987 |
|
Biochemical assay | Fluorescence Polarization | pIC50 (half maximal inhibitory concentration, -log10) | 4.83 |
Ta | Structure | Name | Drugbank ID |
---|---|---|---|
0.4574 | Flumazenil | DB01205 | |
0.4541 | Cimicoxib | DB05095 | |
0.4434 | Azeliragon | DB12689 | |
0.4346 | AZD-7687 | DB14949 | |
0.4324 | 4-[4-(4-Fluorophenyl)-2-[4-[(R)-methylsulfinyl]phenyl]-1H-imidazol-5-yl]pyridine | DB08521 | |
0.4324 | Conivaptan | DB00872 | |
0.4271 | PF-03463275 | DB11993 | |
0.4203 | Basimglurant | DB11833 | |
0.4199 | 2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide | DB03509 | |
0.4192 | Iomazenil | DB14971 | |
0.4126 | L-778123 | DB07227 | |
0.4018 | Midazolam | DB00683 | |
0.4011 | 4-(4-FLUOROPHENYL)-1-CYCLOROPROPYLMETHYL-5-(4-PYRIDYL)-IMIDAZOLE | DB08522 | |
0.4000 | Ralimetinib | DB11787 | |
0.3983 | Atorvastatin | DB01076 |