Compound 1441
Identifiers
- Canonical SMILES:
OC(=O)[C@@H](N1[C@@H](c2ccc(Cl)cc2)C(=O)Nc2ccc(cc2C1=O)C#C)c1ccc(Cl)cc1
- IUPAC name:
2-(4-chlorophenyl)-2-[3-(4-chlorophenyl)-7-ethynyl-2,5-dioxo-1,3-dihydro-1,4-benzodiazepin-4-yl]acetic acid
- InChi:
InChI=1S/C25H16Cl2N2O4/c1-2-14-3-12-20-19(13-14)24(31)29(22(25(32)33)16-6-10-18(27)11-7-16)21(23(30)28-20)15-4-8-17(26)9-5-15/h1,3-13,21-22H,(H,28,30)(H,32,33)/t21-,22-/m0/s1
- InChiKey:
ZFMQFYUAXREPEG-VXKWHMMOSA-N
External links
![]() 44390656 |
![]() CHEMBL359897 |
![]() 23246678 |
External search
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Bibliography (1)
Pharmacological data
Biochemical tests | Cellular tests | PK tests | Cytotoxicity tests |
---|---|---|---|
1 | 0 | 0 | 0 |
Targets
PPI family | Best activity | Diseases | MMoA |
---|---|---|---|
MDM2-Like / P53 | 6.06 | cancer | Inhibition |
Physicochemical filters
Descriptor | Lipinski's RO5 | Veber | Pfizer's 3/75 | |
---|---|---|---|---|
Compliance | ||||
MW | 478.05 g/mol | |||
HBA | 6 | |||
HBD | 2 | |||
HBA + HBD | 8 | |||
AlogP | 5.57 | |||
TPSA | 86.71 | |||
RB | 4 |
Radar chart
PCA : iPPI-DB chemical space
PCA : Correlation circle
Efficiencies: iPPI-DB biplot LE versus LLE
Summary
Bibliographic ressources | Biochemical tests | Cellular tests | PK tests | Cytotoxicity tests |
---|---|---|---|---|
1 | 1 | 0 | 0 | 0 |
Ta | Structure | Name | Drugbank ID |
---|---|---|---|
0.5188 | Fominoben | DB08968 | |
0.4970 | Bentiromide | DB00522 | |
0.4774 | Oxazolam | DB15491 | |
0.4695 | [(2S)-4-methyl-3-oxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-2-yl]acetic acid | DB08717 | |
0.4688 | OPC-28326 | DB05461 | |
0.4639 | [1-(3-CHLORO-2-FORMYL-PHENYLCARBAMOYL)-2-METHYL-PROPYL]-CARBAMIC ACID TERT-BUTYL ESTER | DB07956 | |
0.4610 | Evocalcet | DB12388 | |
0.4540 | Indoprofen | DB08951 | |
0.4498 | (1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate | DB08498 | |
0.4491 | (2s)-2-[(2,4-Dichloro-Benzoyl)-(3-Trifluoromethyl-Benzyl)-Amino]-3-Phenyl-Propionic Acid | DB03605 | |
0.4485 | ALPHA-(2,6-DICHLOROPHENYL)-ALPHA-(2-ACETYL-5-METHYLANILINO)ACETAMIDE | DB07332 | |
0.4466 | Cloxazolam | DB01553 | |
0.4464 | 2-{[N-(2-ACETYL-5-CHLORO-4-FLUOROPHENYL)GLYCYL]AMINO}BENZOIC ACID | DB07085 | |
0.4450 | Ioxaglic acid | DB09313 | |
0.4438 | Granotapide | DB12934 |