Compound 1417
Identifiers
- Canonical SMILES:
COCCOCCN1c2ccc(I)cc2C(=O)N([C@H](C)c2ccc(Cl)nc2N)[C@@H](c2ccc(Cl)cc2)C1=O
- IUPAC name:
4-[1-(2-amino-6-chloropyridin-3-yl)ethyl]-3-(4-chlorophenyl)-7-iodo-1-[2-(2-methoxyethoxy)ethyl]-3H-1,4-benzodiazepine-2,5-dione
- InChi:
InChI=1S/C27H27Cl2IN4O4/c1-16(20-8-10-23(29)32-25(20)31)34-24(17-3-5-18(28)6-4-17)27(36)33(11-12-38-14-13-37-2)22-9-7-19(30)15-21(22)26(34)35/h3-10,15-16,24H,11-14H2,1-2H3,(H2,31,32)/t16-,24+/m1/s1
- InChiKey:
JQUVOBLYKVLLHK-GYCJOSAFSA-N
External links
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Bibliography (1)
Pharmacological data
Biochemical tests | Cellular tests | PK tests | Cytotoxicity tests |
---|---|---|---|
1 | 0 | 0 | 0 |
Targets
PPI family | Best activity | Diseases | MMoA |
---|---|---|---|
MDM2-Like / P53 | 4.94 | cancer | Inhibition |
Physicochemical filters
Descriptor | Lipinski's RO5 | Veber | Pfizer's 3/75 | |
---|---|---|---|---|
Compliance | ||||
MW | 668.05 g/mol | |||
HBA | 8 | |||
HBD | 2 | |||
HBA + HBD | 10 | |||
AlogP | 4.96 | |||
TPSA | 97.99 | |||
RB | 9 |
Radar chart
PCA : iPPI-DB chemical space
PCA : Correlation circle
Efficiencies: iPPI-DB biplot LE versus LLE
Summary
Bibliographic ressources | Biochemical tests | Cellular tests | PK tests | Cytotoxicity tests |
---|---|---|---|---|
1 | 1 | 0 | 0 | 0 |
Ta | Structure | Name | Drugbank ID |
---|---|---|---|
0.4800 | LY-3039478 | DB12050 | |
0.4797 | MK-3207 | DB12424 | |
0.4718 | Fominoben | DB08968 | |
0.4641 | Motesanib | DB05575 | |
0.4627 | Ubrogepant | DB15328 | |
0.4596 | Epelsiban | DB11934 | |
0.4580 | (1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate | DB08498 | |
0.4569 | Tariquidar | DB06240 | |
0.4531 | Danusertib | DB11778 | |
0.4502 | (1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate | DB08497 | |
0.4383 | Oxazolam | DB15491 | |
0.4335 | Boscalid | DB12792 | |
0.4305 | Talmapimod | DB05412 | |
0.4280 | M-2698 | DB15431 | |
0.4254 | Acyline | DB11906 |