Compound 1416
Identifiers
- Canonical SMILES:
CCOc1cc(ccc1C1=N[C@H]([C@@H](N1C(=O)N(C)c1ccccn1)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(F)(F)F
- IUPAC name:
4,5-bis(4-chlorophenyl)-2-[2-ethoxy-4-(trifluoromethyl)phenyl]-N-methyl-N-pyridin-2-yl-4,5-dihydroimidazole-1-carboxamide
- InChi:
InChI=1S/C31H25Cl2F3N4O2/c1-3-42-25-18-21(31(34,35)36)11-16-24(25)29-38-27(19-7-12-22(32)13-8-19)28(20-9-14-23(33)15-10-20)40(29)30(41)39(2)26-6-4-5-17-37-26/h4-18,27-28H,3H2,1-2H3/t27-,28-/m0/s1
- InChiKey:
UNKGINWJIXGLGX-NSOVKSMOSA-N
External links
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External search
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Bibliography (1)
Publication | Name |
---|---|
Gregory Jay Haley, Norman Kong, Emily Aijun Liu, Klaus B. Simonsen, Binh Thanh Vu, Stephen Evan Webber, F. Hoffmann-La Roche Ag. . Cis-2,4,5-triaryl-imidazolines None. | 36 |
Pharmacological data
Biochemical tests | Cellular tests | PK tests | Cytotoxicity tests |
---|---|---|---|
1 | 0 | 0 | 0 |
Targets
PPI family | Best activity | Diseases | MMoA |
---|---|---|---|
MDM2-Like / P53 | 5.37 | cancer | Inhibition |
Physicochemical filters
Descriptor | Lipinski's RO5 | Veber | Pfizer's 3/75 | |
---|---|---|---|---|
Compliance | ||||
MW | 612.13 g/mol | |||
HBA | 6 | |||
HBD | 0 | |||
HBA + HBD | 6 | |||
AlogP | 8.10 | |||
TPSA | 58.03 | |||
RB | 7 |
Radar chart
PCA : iPPI-DB chemical space
PCA : Correlation circle
Efficiencies: iPPI-DB biplot LE versus LLE
Summary
Bibliographic ressources | Biochemical tests | Cellular tests | PK tests | Cytotoxicity tests |
---|---|---|---|---|
1 | 1 | 0 | 0 | 0 |
Pharmacological data
Bibliography | Name | Target | Competition | Assay type | Assay name | Cell line | Activity type | Activity |
---|---|---|---|---|---|---|---|---|
WO2005003097 | 36 | MDM2 Q00987 |
|
Biochemical assay | Time-Resolved FRET | pIC50 (half maximal inhibitory concentration, -log10) | 5.37 |
Ta | Structure | Name | Drugbank ID |
---|---|---|---|
0.7348 | Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone | DB04144 | |
0.7250 | RO-5045337 | DB14793 | |
0.6570 | Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone | DB02872 | |
0.4073 | PCO-371 | DB14946 | |
0.3923 | 1-(5-BROMO-PYRIDIN-2-YL)-3-[2-(6-FLUORO-2-HYDROXY-3-PROPIONYL-PHENYL)-CYCLOPROPYL]-UREA | DB07451 | |
0.3783 | 1-[2-(3-ACETYL-2-HYDROXY-6-METHOXY-PHENYL)-CYCLOPROPYL]-3-(5-CYANO-PYRIDIN-2-YL)-THIOUREA | DB08212 | |
0.3768 | Metralindole | DB09306 | |
0.3750 | Copanlisib | DB12483 | |
0.3688 | Olcegepant | DB04869 | |
0.3688 | Tarazepide | DB06435 | |
0.3686 | ONO-2952 | DB14802 | |
0.3667 | Imazaquin | DB04582 | |
0.3618 | PRI-724 | DB15034 | |
0.3594 | [4-({[5-Benzyloxy-1-(3-Carbamimidoyl-Benzyl)-1h-Indole-2-Carbonyl]-Amino}-Methyl)-Phenyl]-Trimethyl-Ammonium | DB02269 | |
0.3589 | N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide | DB06995 |