Compound 1414
Identifiers
- Canonical SMILES:
Cc1cccc(c1)-c1nc(C(=O)NOCc2ccccc2)c(-c2cccc(Cl)c2)n1-c1cc(Cl)ccc1C
- InChi:
InChI=1S/C31H25Cl2N3O2/c1-20-8-6-12-24(16-20)30-34-28(31(37)35-38-19-22-9-4-3-5-10-22)29(23-11-7-13-25(32)17-23)36(30)27-18-26(33)15-14-21(27)2/h3-18H,19H2,1-2H3,(H,35,37)
- InChiKey:
DGJDLWCKEMZPQZ-UHFFFAOYSA-N
External links
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Bibliography (1)
Pharmacological data
Biochemical tests | Cellular tests | PK tests | Cytotoxicity tests |
---|---|---|---|
1 | 0 | 0 | 0 |
Targets
PPI family | Best activity | Diseases | MMoA |
---|---|---|---|
MDM2-Like / P53 | 6.09 | cancer | Inhibition |
Physicochemical filters
Descriptor | Lipinski's RO5 | Veber | Pfizer's 3/75 | |
---|---|---|---|---|
Compliance | ||||
MW | 541.13 g/mol | |||
HBA | 5 | |||
HBD | 1 | |||
HBA + HBD | 6 | |||
AlogP | 8.22 | |||
TPSA | 56.15 | |||
RB | 6 |
Radar chart
PCA : iPPI-DB chemical space
PCA : Correlation circle
Efficiencies: iPPI-DB biplot LE versus LLE
Summary
Bibliographic ressources | Biochemical tests | Cellular tests | PK tests | Cytotoxicity tests |
---|---|---|---|---|
1 | 1 | 0 | 0 | 0 |
Pharmacological data
Bibliography | Name | Target | Competition | Assay type | Assay name | Cell line | Activity type | Activity |
---|---|---|---|---|---|---|---|---|
WO2011023677 | 53 | MDM2 Q00987 |
|
Biochemical assay | Fluorescence Polarization | pIC50 (half maximal inhibitory concentration, -log10) | 6.09 |
Ta | Structure | Name | Drugbank ID |
---|---|---|---|
0.4210 | Iomazenil | DB14971 | |
0.4040 | Flumazenil | DB01205 | |
0.4008 | Azeliragon | DB12689 | |
0.3984 | Conivaptan | DB00872 | |
0.3954 | AZD-7687 | DB14949 | |
0.3941 | 2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide | DB03509 | |
0.3868 | Miransertib | DB14982 | |
0.3856 | Cimicoxib | DB05095 | |
0.3803 | Telmisartan | DB00966 | |
0.3750 | N-6022 | DB12206 | |
0.3701 | Otenabant | DB11745 | |
0.3664 | L-778123 | DB07227 | |
0.3624 | Zolpidem | DB00425 | |
0.3618 | Olmesartan | DB00275 | |
0.3553 | Saprisartan | DB01347 |