Efficiency plot: Ligand efficiency (LE) versus Lipophilic Efficiency (LLE)
- LE: Ligand Efficiency
- LLE: Lipophilic Efficiency
For the calculation of the efficiencies, we select a reference activity such that Ki and Kd are favored over IC50 and EC50 and biochemical assays over cellular assays.
iPPI-DB biplot of Ligand Efficiency (LE = 1.37 x pXC50 / No heavy atoms) versus Lipophilic Ligand Efficiency (LLE = pXC50 - AlogP) where pXC50 is any of the following: pKd, pKi, pIC50 or pEC50. Each iPPI is colored according to their corresponding target.