Contributors
Karen Druart
Published contributions number
- 11 publications
- 0 patents
- 73 compounds
- 165 pharmacological data
- 11 PPI targets
Scientific publications and patents
- Filippakopoulos Panagis, Picaud Sarah, Fedorov Oleg, Keller Marco, Wrobel Matthias, Morgenstern Olaf, Bracher Franz, Knapp Stefan. . Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family Bioorganic & Medicinal Chemistry.
- Cossu Federica, Malvezzi Francesca, Canevari Giulia, Mastrangelo Eloise, Lecis Daniele, Delia Domenico, Seneci Pierfausto, Scolastico Carlo, Bolognesi Martino, Milani Mario. . Recognition of Smac-mimetic compounds by the BIR domain of cIAP1 Protein Science.
- Asano Moriteru, Hashimoto Kentaro, Saito Bunnai, Shiokawa Zenyu, Sumi Hiroyuki, Yabuki Masato, Yoshimatsu Mie, Aoyama Kazunobu, Hamada Teruki, Morishita Nao, Dougan Douglas R., Mol Clifford D., Yoshida Sei, Ishikawa Tomoyasu. . Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists Bioorganic & Medicinal Chemistry.
- Arkin M. R., Randal M., DeLano W. L., Hyde J., Luong T. N., Oslob J. D., Raphael D. R., Taylor L., Wang J., McDowell R. S., Wells J. A., Braisted A. C.. . Binding of small molecules to an adaptive protein-protein interface Proceedings of the National Academy of Sciences.
- Holzer Philipp, Masuya Keiichi, Furet Pascal, Kallen Joerg, Valat-Stachyra Therese, Ferretti Stéphane, Berghausen Joerg, Bouisset-Leonard Michèle, Buschmann Nicole, Pissot-Soldermann Carole, Rynn Caroline, Ruetz Stephan, Stutz Stefan, Chène Patrick, Jeay Sébastien, Gessier Francois. . Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors Journal of Medicinal Chemistry.
- Gollner Andreas, Rudolph Dorothea, Arnhof Heribert, Bauer Markus, Blake Sophia M., Boehmelt Guido, Cockroft Xiao-Ling, Dahmann Georg, Ettmayer Peter, Gerstberger Thomas, Karolyi-Oezguer Jale, Kessler Dirk, Kofink Christiane, Ramharter Juergen, Rinnenthal Jörg, Savchenko Alexander, Schnitzer Renate, Weinstabl Harald, Weyer-Czernilofsky Ulrike, Wunberg Tobias, McConnell Darryl B.. . Discovery of Novel Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2–p53 Interaction Journal of Medicinal Chemistry.
- Tovar C., Graves B., Packman K., Filipovic Z., Xia B. H. M., Tardell C., Garrido R., Lee E., Kolinsky K., To K.-H., Linn M., Podlaski F., Wovkulich P., Vu B., Vassilev L. T.. . MDM2 Small-Molecule Antagonist RG7112 Activates p53 Signaling and Regresses Human Tumors in Preclinical Cancer Models Cancer Research.
- Yu Ming, Wang Yingcai, Zhu Jiang, Bartberger Michael D., Canon Jude, Chen Ada, Chow David, Eksterowicz John, Fox Brian, Fu Jiasheng, Gribble Michael, Huang Xin, Li Zhihong, Liu Jiwen (Jim), Lo Mei-chu, McMinn Dustin, Oliner Jonathan D., Osgood Tao, Rew Yosup, Saiki Anne Y., Shaffer Paul, Yan Xuelei, Ye Qiuping, Yu Dongyin, Zhao Xiaoning, Zhou Jing, Olson Steven H., Medina Julio C., Sun Daqing. . Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2–p53 Interaction ACS Medicinal Chemistry Letters.
- Grasberger Bruce L., Lu Tianbao, Schubert Carsten, Parks Daniel J., Carver Theodore E., Koblish Holly K., Cummings Maxwell D., LaFrance Louis V., Milkiewicz Karen L., Calvo Raul R., Maguire Diane, Lattanze Jennifer, Franks Carol F., Zhao Shuyuan, Ramachandren Kannan, Bylebyl Gwendolyn R., Zhang Marie, Manthey Carl L., Petrella Eugene C., Pantoliano Michael W., Deckman Ingrid C., Spurlino John C., Maroney Anna C., Tomczuk Bruce E., Molloy Christopher J., Bone Roger F.. . Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells Journal of Medicinal Chemistry.
- Vassilev L. T.. . In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2 Science.
- Vu Binh, Wovkulich Peter, Pizzolato Giacomo, Lovey Allen, Ding Qingjie, Jiang Nan, Liu Jin-Jun, Zhao Chunlin, Glenn Kelli, Wen Yang, Tovar Christian, Packman Kathryn, Vassilev Lyubomir, Graves Bradford. . Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development ACS Medicinal Chemistry Letters.